MovDisordV3, Main, Exploration, bibRecord, 004E78

Treatment of restless leg syndrome with pergolide—an open clinical trial

Identifieur interne : 004E78 ( Main/Exploration ); précédent : 004E77; suivant : 004E79

Treatment of restless leg syndrome with pergolide—an open clinical trial

Auteurs : Juliane Winkelmann [Allemagne] ; Thomas C. Wetter [Allemagne] ; Karen Stiasny [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Claudia Trenkwalder [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-05.

RBID : ISTEX:B580E19AF234841174FDD4970327EFA8C103F030

Descripteurs français

Pascal (Inist)
- Agoniste, Chimiothérapie, Ergot dérivé, Homme, Impatience membre inférieur syndrome, Pergolide, Récepteur dopaminergique, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Agonist, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Chemotherapy, Domperidone (adverse effects), Domperidone (therapeutic use), Dopamine receptor, Dose-Response Relationship, Drug, Drug Therapy, Combination, Ergot derivatives, Female, Follow-Up Studies, Human, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Pergolide, Pergolide (adverse effects), Pergolide (therapeutic use), Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (etiology), Restless Legs Syndrome (genetics), Restless leg syndrome, Restless legs syndrome, Therapy, Treatment, Treatment Outcome.
MESH :
- chemical , adverse effects : Antiparkinson Agents, Domperidone, Levodopa, Pergolide.
- chemical , therapeutic use : Antiparkinson Agents, Domperidone, Levodopa, Pergolide.
- drug therapy : Restless Legs Syndrome.
- etiology : Restless Legs Syndrome.
- genetics : Restless Legs Syndrome.
- Aged, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.

Abstract

Dopaminergic treatment with levodopa (L‐dopa) has been proven as the treatment of first choice in patients with restless leg syndrome (RLS). Augmentation of symptoms and end‐of‐dose rebound phenomena under L‐dopa/decarboxylase inhibitor treatment present major problems in some patients. To evaluate the efficacy of pergolide in RLS, we treated 15 patients suffering from severe RLS, who had previously experienced an augmentation of symptoms under long‐term treatment with L‐dopa, in an open clinical trial with pergolide. All patients reported an improvement of their RLS symptoms. Our study shows that pergolide, if administered at a mean dose of 0.4 mg in combination with domperidone, is a very effective drug in the treatment of sleep disturbances and daytime symptoms associated with RLS, and does not cause any serious side effects during the observation period of 6 months.

Url:

https://api.istex.fr/document/B580E19AF234841174FDD4970327EFA8C103F030/fulltext/pdf

DOI: 10.1002/mds.870130333

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Dopaminergic treatment with levodopa (L‐dopa) has been proven as the treatment of first choice in patients with restless leg syndrome (RLS). Augmentation of symptoms and end‐of‐dose rebound phenomena under L‐dopa/decarboxylase inhibitor treatment present major problems in some patients. To evaluate the efficacy of pergolide in RLS, we treated 15 patients suffering from severe RLS, who had previously experienced an augmentation of symptoms under long‐term treatment with L‐dopa, in an open clinical trial with pergolide. All patients reported an improvement of their RLS symptoms. Our study shows that pergolide, if administered at a mean dose of 0.4 mg in combination with domperidone, is a very effective drug in the treatment of sleep disturbances and daytime symptoms associated with RLS, and does not cause any serious side effects during the observation period of 6 months.</div>
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Movement Disorders (revue)

Treatment of restless leg syndrome with pergolide—an open clinical trial

Treatment of restless leg syndrome with pergolide—an open clinical trial

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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